Discover the possibilities "Omicron" Which makes it more transmissible from other SARS-CoV-2 mutants.

A team of researchers has identified new features of the “micron” variant of SARS-CoV-2 that may explain why it is more contagious than other variants of the virus.

In a study published in the journal Proceedings of National Academy of Sciences, researchers at the Gladstone Institute and Curative Corporation used virus-like particles (VLPs) to study the assembly and neutralization potential of the omicron mutant.

With the onset of the epidemic, scientists, as expected, discovered that the SARS-CoV-2 virus had mutated into several variants. Previous research has shown that some mutations make people sicker than others, and also that some are more contagious—they infect people more easily, allowing more people to become infected in a shorter period of time.

One such mutant, omicron, was particularly infectious, and in this new work, the researchers aimed to uncover the underlying cause.

To learn more about the unique characteristics of omicron transmission, the researchers studied virus-like particles rather than the virus itself for safety reasons, as virus-like particles (VLPs) are non-infectious because they do not contain viral genetic material. . During the study, the researchers analyzed the characteristics of four virus-like particle models for four known SARS-CoV-2 mutants Omicron, Delta, B.1.1 and B.1.

All have been tested in antiserum samples (blood serum that contains antibodies and is used to confer passive immunity to many diseases) taken from infected patients.

They found that the patients’ antisera were about 15 times less effective against Omicron than the original B.1 strain, despite the increased neutralizing effect of the two vaccines.

By carefully examining the N mutation, which distinguishes Omicron from other strains, the researchers found that it allows the virus to enter host cells more easily and also increases its aggregation by four and a half times. (Virus assembly is the stage in which the newly synthesized genome (DNA) combines with proteins to form new viral fragments.)

The researchers suggest that Omicron is more contagious due to several factors: its efficient aggregation, its efficient entry into cells, and its ability to neutralize antibodies.

The researchers also evaluated the effectiveness of four main types of monoclonal antibody treatments used to treat coronavirus patients and found that only one type worked well against Omicron, which is bebtelovimab, manufactured by the American company Eli Lilly and Company.

Source: Medical Express