Discovery of effective anti-Alzheimer molecules in green tea

UCLA scientists have discovered compounds in green tea that can break down protein clumps associated with Alzheimer’s in the brain.

And Nature Communications reports that epigallocatechin gallate (EGCG) molecules are known to disrupt tau protein fibrils, which form tangles that cause neuronal death. In their new study, the researchers described how EGCG breaks down tau fibers and found other molecules that perform the same role and penetrate brain tissue very efficiently.

The researchers extracted tau protein clumps from the brains of people who died of Alzheimer’s disease and incubated them for varying times with EGCG. Three hours later, they found that half of the fibers had collapsed and the other half had been partially damaged. After 24 hours, the fibrous tangles completely disappeared.

On the tau fibers, the researchers identified regions called drug transporters that EGCG molecules bind to. Then, using computer simulations, they analyzed information about 60,000 small molecules that potentially bind to the same sites. As a result, researchers have identified several hundred molecules of 25 atoms or less that bind to pharmaceutical tau fibers better than EGCG, including molecules called CNS-11 and CNS-17.

Source: linta. Ro