Innovation of a new drug against bacterial urinary tract infections

A team of scientists from Duke University has created a new drug that fights bacterial urinary tract infections, especially the urinary tract pathogen Escherichia coli (UPEC).

Science Advances notes that UTIs are common, especially among women, due to the structure of the urinary tract. And these diseases can become chronic or lead to complications that can be fatal if left untreated, as they are usually treated with antibiotics, which have health consequences, including bowel problems.

And now scientists have created a new way to fight urinary tract infections, based on a drug that kills pathogenic bacteria. Researchers have previously tried to create similar substances, but they have not been successful due to the difficulty of getting the drug through the cellular mucosa that covers the walls of the mouth, throat and urinary tract.

To get around this problem, the researchers used peptide nanofibers, which not only penetrate the mucosa but also train the immune system to recognize and fight UPEC by targeting three peptides on the bacterial surface. The promising compound is in the form of tablets to be placed under the tongue and then dissolved in saliva.

Experiments conducted on mice and rabbits showed the effectiveness of the new drug, similar to the effectiveness of traditional antibiotics, but without the harmful effects on the digestive system.

The researchers plan to test the new drug in humans. If the compound successfully passes all stages of testing, it will reduce the use of antibiotics, which is important given the development of antibiotic resistance, which has become a global public health problem.

Source: Linta. EN