Scientists at the Don Russian Technological University in Rostov have created a bioreactor that mimics the work of the digestive system of animals.
On Thursday, November 24, the press service of the university reported that the artificial digestive system, which has no analogues in Russia, will significantly increase the efficiency of preclinical studies of pharmacological preparations and nutritional supplements.
Alexander Lukyanov, head of the Department of Automation of Production Processes at the Don University, said that the uniqueness of the bioreactor invented by scientists lies, first of all, in its focus on studying digestion in animals, in contrast to devices designed to study human digestion. , Direct experiments with organisms to the simulation area, i.e. from the system in vivo, into the system in vitro, which not only simplifies and reduces the cost of the research process, but also makes it more ethical.”
In the bioreactor, the influence of pharmaceutical, food and biologically active additives on the microenvironment of animals and the pharmacokinetics of drugs in the gastrointestinal tract is studied. The bioreactor will allow testing the safety and efficacy of drugs and food supplements for the digestive tract of animals. Using the reactor, you can quickly determine the effectiveness of the tested drugs and supplements, as well as conduct clinical studies on animals using only drugs that have passed the preclinical stage and are completely safe for the gastrointestinal tract. intestinal tract. In addition, the reactor will reduce the financial and organizational burden on clinical trials.
One production of a bioreactor can be compared with the use of 10 to 40 animals in medical, preclinical and veterinary clinical studies, depending on the experimental conditions and mathematical expectations, said Igor Popov, head of the microdigestive bioreactor at the Don University. In this way, we save money for our partners, and at the same time, the study respects all the principles of humanity and ethics when conducting experiments, since fewer experimental animals are used.