Study Shows Blood Type That May Affect Early Stroke Risk!

According to a 2022 study, people with blood type A are more likely to have a stroke before the age of 60 than people with other blood types.

Blood groups describe the rich variety of chemicals present on the surface of red blood cells. Among the most common are the so-called A and B, which may exist together as AB, separately as A or B, or not at all as O.

Even within these major blood groups, there are subtle differences that arise from mutations in the responsible genes.

Now, genomic studies have revealed a clear link between the A1 subset gene and premature stroke.

The researchers pooled data from 48 genetic studies that included almost 17,000 people with stroke and nearly 600,000 people without stroke. The age of all participants ranged from 18 to 59 years.

A genome-wide search revealed two loci strongly associated with prior stroke risk. One of them coincided with the place where the blood group genes were located.

A second analysis of the genes for certain blood types found that people whose genomes code for type A were 16% more likely to have a stroke before the age of 60 than people with other blood types.

And for those with the O1 gene group, the risk was 12% lower.

However, the researchers note that the additional risk of stroke in people with blood type A is small, so there is no need for extra vigilance or screening in this group.

“We still don’t know why blood type A poses a greater risk,” Stephen Kittner, senior author on neuroscience and vascular sciences at the University of Maryland, said in a 2022 statement. But it likely has something to do with clotting factors. . such as platelets, cells that line blood vessels, plus other circulating proteins, all of which play a role in the formation of blood clots.”

While the results of the study may sound alarming and that this blood type may change the risk of early stroke, let’s put these findings in context.

The people who participated in the study lived in North America, Europe, Japan, Pakistan, and Australia, and people of non-European descent made up only 35 percent of the participants. Future studies with more diverse samples may help clarify the significance of the results.

“Obviously, we need more research to elucidate the mechanisms behind the increased risk of stroke,” Kittner said.

Another key finding of the study came from comparing people who had a stroke before age 60 with those who had a stroke after age 60.

For this purpose, the researchers used a dataset of approximately 9,300 people over 60 who had a stroke and about 25,000 people over 60 who had not had a stroke.

They found that the increased risk of stroke in blood type A became negligible in the late stroke group, suggesting that strokes that occur early in life may have a different mechanism than those that occur later.

Researchers say strokes in young people are less likely to be caused by fatty deposits in the arteries (a process called atherosclerosis) and more likely to be caused by factors associated with blood clots.

The study also found that people with blood type B were almost 11% more likely to have a stroke than people without a stroke, regardless of their age.

Previous research suggests that the part of the genome that codes for the blood group, called the ABO locus, is associated with blood-limiting coronary artery calcification and heart attacks.

The genetic sequences of blood types A and B have also been associated with a slightly increased risk of blood clots in the veins, called venous thrombosis.

This article was published in neurology.

Source: Science Alert